DCS Migration Project on Downstream Process for Bio-Pharmaceutical Company
Location: Pennsylvania, USA
Process: Microbial Fermentation
Scope: Recovery, Purification, Formulation and Buffer Areas
Zenith was awarded the Functional Specification authoring and development of the downstream portion of a 8,000 I/O Provox to DeltaV migration. The facility was to be converted from a Cell Culture facility to Microbial Fermentation and all equipment was replaced to accommodate increased capacity. Areas under Zenith’s responsibility were Recovery, Buffer, Purification and Formulation which included Centrifuge, Chromatography, UF/DF, Inline Dilution and various vessel unit operations. In order to meet the schedule deadlines an integrated commissioning and validation approach was used requiring the leveraging of software FATs.